What is the standard tranexamic acid dosage for postpartum hemorrhage when indicated?

• A. Tranexamic Acid 1 g IV/IO in 100 mL NS over 10 minutes
• B. 2 g PO
• C. 0.5 g IM
• D. 1 g Subcutaneous

Answer: (A)

In postpartum hemorrhage, tranexamic acid is used to rapidly inhibit fibrinolysis and help stop bleeding. The standard dosing is 1 g given IV or IO over about 10 minutes, with a second 1 g dose possible if bleeding continues (for a total of up to 2 g). Delivering it as 1 g in 100 mL of normal saline over 10 minutes matches this standard. Oral administration is slower and not suitable for acute bleed, and intramuscular or subcutaneous routes are not the usual, effective approaches in this situation.