What is the minimum number of Epinephrine doses required prior to termination decisions?

• A. At least four
• B. Two
• C. One
• D. None

Answer: (A)

During CPR, epinephrine is given to boost perfusion to the heart and brain by increasing diastolic aortic pressure and overall perfusion during chest compressions. Before making termination decisions, a sufficient trial of this therapy is kept in mind so that we don’t conclude futility too soon. Administering epinephrine at least four times provides enough opportunity to assess whether repeated vasopressor support is producing any meaningful improvement, such as return of circulation or better perfusion, before deciding to stop resuscitation. Fewer than four doses may not reveal the treatment’s potential effect, and giving none would skip this assessment entirely. Thus, four doses is the minimum expected before termination decisions are considered.