In the context of anaphylaxis, which statement about angioedema is true?

• A. Angioedema is a sign of a severe reaction.
• B. Angioedema always indicates a mild reaction.
• C. Angioedema only involves the skin.
• D. Angioedema rules out anaphylaxis.

Answer: (A)

In anaphylaxis, angioedema signals that mediators are causing swelling in deeper tissues, often around the face, lips, tongue, and throat. That swelling can threaten the airway and is part of a systemic reaction, so its presence indicates a potentially severe allergic response. It isn’t limited to mild cases, isn’t confined to the skin, and its occurrence does not rule out anaphylaxis. If angioedema appears with other symptoms like trouble breathing, throat tightness, or low blood pressure, it requires urgent evaluation and treatment, including prompt use of epinephrine.