If a second dose of Amiodarone is given after the initial 300 mg, what amount is used?

• A. 150 mg
• B. 300 mg
• C. 450 mg
• D. 100 mg

Answer: (A)

After the initial 300 mg IV bolus, a second bolus of 150 mg is given if the arrhythmia persists. This brings the total bolus exposure to 450 mg, which is the standard ceiling before starting the infusion. The smaller second dose maintains antiarrhythmic effect while balancing toxicity risk. The other amounts don’t align with the typical ACLS dosing: 300 mg as a second dose would exceed the standard bolus approach, 450 mg would exceed the recommended total bolus after two doses, and 100 mg is not a standard bolus amount.